alpha-Synuclein Antibody (2E4.) Summary
| Immunogen |
SNCA (NP_000336, 31 a.a. – 140 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
|
| Localization |
Cytoplasm. Membrane. Nucleus. Membrane-bound in dopaminergic neurons. Also found in the nucleus.
|
| Specificity |
SNCA – synuclein, alpha (non A4 component of amyloid precursor)
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SNCA
|
| Purity |
IgG purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for alpha-Synuclein Antibody (2E4.)
- alpha-Synuclein
- Lewy body) 4
- MGC110988
- NACP
- non A-beta component of AD amyloid
- Non-A beta component of AD amyloid
- Non-A4 component of amyloid precursor
- non-A4 component of amyloid
- PARK1
- PARK4
- PD1
- SNCA
- synuclein, alpha (non A4 component of amyloid precursor)
- Synuclein-alpha
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.