Product Name :
NSC305787 hydrochloride
Description:
NSC305787 hydrochloride is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity.
CAS:
53868-26-1
Molecular Weight:
481.89
Formula:
C25H31Cl3N2O
Chemical Name:
[2-(adamantan-1-yl)-6,8-dichloroquinolin-4-yl](piperidin-2-yl)methanol hydrochloride
Smiles :
Cl.OC(C1CCCCN1)C1=CC(=NC2=C1C=C(Cl)C=C2Cl)C12CC3CC(C1)CC(C2)C3
InChiKey:
JQALIVSYOXLOBE-UHFFFAOYSA-N
InChi :
InChI=1S/C25H30Cl2N2O.ClH/c26-17-8-18-19(24(30)21-3-1-2-4-28-21)10-22(29-23(18)20(27)9-17)25-11-14-5-15(12-25)7-16(6-14)13-25;/h8-10,14-16,21,24,28,30H,1-7,11-13H2;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NSC305787 hydrochloride is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity.|Product information|CAS Number: 53868-26-1|Molecular Weight: 481.89|Formula: C25H31Cl3N2O|Chemical Name: [2-(adamantan-1-yl)-6,8-dichloroquinolin-4-yl](piperidin-2-yl)methanol hydrochloride|Smiles: Cl.{{Ponatinib} web|{Ponatinib} Protein Tyrosine Kinase/RTK|{Ponatinib} Protocol|{Ponatinib} In stock|{Ponatinib} manufacturer|{Ponatinib} Epigenetic Reader Domain} OC(C1CCCCN1)C1=CC(=NC2=C1C=C(Cl)C=C2Cl)C12CC3CC(C1)CC(C2)C3|InChiKey: JQALIVSYOXLOBE-UHFFFAOYSA-N|InChi: InChI=1S/C25H30Cl2N2O.{{Tremelimumab} MedChemExpress|{Tremelimumab} CTLA-4|{Tremelimumab} Purity & Documentation|{Tremelimumab} Description|{Tremelimumab} manufacturer|{Tremelimumab} Epigenetics} ClH/c26-17-8-18-19(24(30)21-3-1-2-4-28-21)10-22(29-23(18)20(27)9-17)25-11-14-5-15(12-25)7-16(6-14)13-25;/h8-10,14-16,21,24,28,30H,1-7,11-13H2;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 8 mg/mL (16.PMID:23554582 60 mM; Need ultrasonic and warming). H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NSC305787 hydrochloride is an inhibitor of ezrin with a Kd of 5.85 μM, and has antitumor activity. NSC305787 inhibits PKCΙ phosphorylation of Ezrin, Moesin, Radixin, MBP, with IC50s of 8.3, 9.4, 55, 58.9 μM, respectively. NSC305787 binds to PKCΙ with a Kd value of 172.4 μM, and inhibits ezrin T567 phosphorylation primarily via its binding to ezrin and not through inhibition of PKCΙ kinase activity. NSC305787 (1, 10 μM) shows inhibitory activity against ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells. Moreover, NSC305787 (10 μM) reduces cell motility phenotypes in zebrafish and blocks OS metastatic growth in lung organ culture.|In Vivo:|NSC305787 (0.240 mg/kg/day, i.p.) suppresses ezrin-dependent osteosarcoma metastatic growth in mouse lung. NSC305787 (240 μg/kg, i.p.) dramatically inhibits pulmonary metastasis in a transgenic mouse model of osteosarcoma (Osx-Cre+p53fl/flpRBfl/fl) and shows a more favorable pharmacokinetic profile compared with NSC668394 in the mouse model.|Products are for research use only. Not for human use.|