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ORIGINAL RESEARCHInsight and Treatment Outcomes in Schizophrenia: Post-hoc
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ORIGINAL RESEARCHInsight and Treatment Outcomes in Schizophrenia: Post-hoc Analysis of a Long-term, Double-blind Study Comparing Lurasidone and Quetiapine XRABSTRACTABSTRACT: Objective: The objective of this post-hoc analysis was to evaluate the effect of lurasidone and quetiapine extended-release (XR) on insight and judgment and assess the longitudinal relationships amongst improvement in insight and cognitive overall performance, functional capacity, quality of well-being, and depressive symptoms in sufferers with schizophrenia. Design: Clinically unstable individuals with schizophrenia (N=488) were randomized to once-daily, fixed-dose remedy with lurasidone 80mg, lurasidone 160mg, quetiapine XR 600mg, or placebo, followed by a long-term, double-blind, flexible-dose continuation study involving these agents. Outcomes: Significantly greater improvement in insight and judgment (assessed by the Constructive and Adverse Syndrome Scale G12 item) for the lurasidone and quetiapine XR groups, when compared with the placebo group, was observed at Week six. More than a subsequent six-month continuation period, the versatile dose lurasidone group showed considerably higher improvement in insight from acute phase baseline compared to the flexible-dose quetiapine XR group (QXR-QXR) (p=0.032). Improvement in insight was significantly correlated with improvement in cognition (p=0.014), functional capacity (p=0.006, UPSA-B), good quality of well-being (p=0.033, QWB), and depressive symptoms (p=0.05, Montgomery��sberg Depression Rating Scale [MADRS] score) across therapy groups and study periods. Conclusion: In this post-hoc evaluation, flexibly dosed lurasidone 40 to 160mg/d was identified to become linked with considerably greater improvement in insight when compared with flexibly dosed quetiapine XR 200 to 800mg/d over long-term therapy in sufferers with schizophrenia. Across therapy groups, improvement in insight and judgment was drastically connected with improvement in cognition, functional capacity, high quality of well-being, and depressive symptoms over time. Keywords and phrases: Insight, schizophrenia, cognition, functional capacity, quality of well-being, depressive symptoms, lurasidone, quetiapine XRby PHILIP D. HARVEY, PhD; CYNTHIA O. SIU, PhD; and ANTONY D. LOEBEL, MDDr. Harvey is together with the University of Miami Miller School of Medicine in Miami, Florida, plus the Analysis Service in the Bruce W. Carter VA Health-related Center in Miami, Florida. Dr. Siu is with COS and Associates Ltd. in Central District, Hong Kong. Dr. Loebel is with Sunovion Pharmaceuticals Inc., in Fort Lee, New Jersey.PInnov Clin Neurosci. 2017;14(11sirtuininhibitor2):23sirtuininhibitorPoor insight, which includes impairments in awareness of illness, frequently happens in sufferers with schizophrenia and represents a significant risk issue for poor therapy outcomes.Desmin/DES Protein supplier 1sirtuininhibitor Lowered insight has been found to become linked with poor treatment adherence;8sirtuininhibitor1 a lot more extreme symptoms of illness;three and many deficits in cognition, social cognition, and functional functionality.VEGF-C Protein site four,6,eight Improving insight is hence a important therapeutic aim for sufferers with schizophrenia.PMID:23290930 12 Poor insight in schizophrenia has been linked to reduced awareness on the presence and significance of psychotic symptoms,13,14 impaired self-assessment of cognitive and functional functionality,15 deficits in appraising and responding to effort-based tasks,16 and decreased subjective top quality of well-being.five,12,17sirtuininhibitor0 A recent study suggest.