Recombinant Human FUS Protein Summary
| Description |
A full-length protein with an N-terminal His tag and corresponding to amino acids 1 – 526 of FUS.
Source: E. coli Amino Acid Sequence: MGSSHHHHHHHHGQNLYFQGAMSASNDYTQQATQSYGA YPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSS YSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYG QQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSY SQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGG GGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGG SGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEP RGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQD NSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLY TDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSF ATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGR GGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQC KAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGR GGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY |
| Protein/Peptide Type |
Full Length Recombinant Protein
|
| Gene |
FUS
|
Packaging, Storage & Formulations
| Storage |
Store at -80C. Avoid freeze-thaw cycles.
|
| Buffer |
25 mM Tris pH 8.0, 250 mM NaCl, 8 M Urea, 1 mM DTT
|
| Concentration |
0.5 mg/ml
|
Notes
This FUS Protein has a Purity >95%. This product was tested in Western Blot using NB100-562. The antibody was used to detect 60ng on the western blot.
Alternate Names for Recombinant Human FUS Protein
- 75 kDa DNA-pairing protein
- ALS6
- amyotrophic lateral sclerosis 6
- FUS1
- fused in sarcoma
- fusion (involved in t(12;16) in malignant liposarcoma)
- fusion gene in myxoid liposarcoma
- fusion, derived from t(12;16) malignant liposarcoma
- fus-like protein
- heterogeneous nuclear ribonucleoprotein P2
- HNRNPP2
- Oncogene FUS
- Oncogene TLS
- POMP75
- RNA-binding protein FUS
- TLShnRNP-P2
- Translocated in liposarcoma protein
Background
Tyrosine FUS is a nucleic acid-binding protein whose N-terminal half functions as a transcriptional activator domain in fusion oncoproteins found in human leukemias and liposarcomas. FUS has been reported to be associated with the nuclear matrix and has been implicated in transcription, pre-mRNA splicing processes, spliceosome assembly, and promoting undifferentiated endothelial cells. Human FUS with an N-terminal His tag expressed in E. coli and purified by conventional chromatography.