sferring phosphorus-containing groups Extrinsic component of membrane Membrane raft CC Membrane microdomain Membrane area Phosphatidylinositol-3-kinase complex Growth issue activity BMP receptor CBP/p300 Inhibitor Formulation binding 1-phosphatidylinositol-3-kinase regulator activity Phosphatidylinositol-3-kinase regulator activity Transmembrane receptor protein serine/threonine kinase binding Receptor senrine/threonine kinase binding Phosphotyrosine residue binding 0.075 0.100 0.125 0.150 Gene ratio Count two 3 0.175 Target genes p.adjustBP MF0.0.0.0.Biological_processCellular_ componentMolecular_ function4(a)p.adjust FoxO signaling pathway Estrogen signaling pathway Drug metabolism-cytochrome P450 TGF-beta signaling pathway Proteoglycans in cancer Human immunodeficiency virus 1 infection Relaxin signaling pathway Apelin signaling pathway Shigellosis Acute myeloid leukemia Retinol metabolism Prolactin signaling pathway JAK-STAT signaling pathway Chronic myeloid leukemia ErbB signaling pathway Phosphatidylinositol signaling program Endocrine resistance AGE-RAGE signaling pathway in diabetic complications C-type lectin receptor signaling pathway Circadian rhythm 0 1 2 three four five FoxO signaling pathway Estrogen signaling pathway Proteoglycans in cancer Human immunodeficiency virus 1 infection Shigellosis Drug metabolism-cytochrome P450 TGF-beta signaling pathway Relaxin signaling pathway Apelin signaling pathway JAK-STAT signaling pathway Acute myeloid leukemia Retinol metabolism Prolactin signaling pathway Chronic myeloid leukemia ErbB signaling pathway Phosphatidylinositol signaling system Endocrine resistance AGE-RAGE signaling pathway in diabetic complications C-type lectin receptor signaling pathway Circadian rhythm 0.075 Count two 3 four 5 0.100 0.125 0.150 0.0.0.0.0.Gene ratio(b)Figure 5: (a) GO functional enrichment analysis; (b) KEGG signal pathway enrichment evaluation.proliferation, and apoptosis. As shown in Figure 8, the fluorescence intensity of FOXO3 in the nucleus from the model group was considerably larger than that with the regular group right after OA induction, indicating that the OA induction inhibited the transfer of FOXO3 for the cytoplasm, and the accumulation of FOXO3 within the nucleus improved. Although after administration of PCE, the fluorescence intensity inside the nucleus decreased within a dose-dependent manner, plus the relative content of FOXO3 inside the cytoplasm enhanced, indicating that PCE could promote the phosphorylation of AKT and induce the CYP3 Activator Formulation gradual transfer of FOXO3 to the cytoplasm. As shown in Figure 9, DAPI emits blue fluorescence upon binding for the nucleus, plus the intensity of green fluorescence and red fluorescence represents the expression level of p-AKT and AKT, respectively. Compared together with the standard group of cells, the expression of p-AKT was significantlyinhibited inside the OA-induced cells. Whilst compared together with the model group, the fluorescence intensity of p-AKT was strengthened with an growing dose of PCE, indicating that the mechanism of PCE for preventing and treating hyperlipidemia might be associated with the enhancement of AKT phosphorylation. The expression of AKT in OA-treated cells appeared to be decreased but not statistically significant. Subsequent WB experiments confirmed the above benefits, as shown in Figure 8(b). Compared with regular cells, after 24 hours of OA induction, the effect of AKT phosphorylation in HepG2 cells was drastically inhibited, when no substantial modifications inside the expression of AKT were evident. Even so, compared with the m
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