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Corneal neovascularization is really a category of pathological angiogenesis that threatens the vision and in some cases causes blindness (Ueta et al., 2019; Cho et al., 2020). Pro-angiogenic factors and anti-angiogenic aspects are two counterbalancing systems that identify the formation of new blood vessels (Senturk et al., 2016; Wang et al., 2019). Inflammation and other causes can break the balance from the two systems, consequently resulting in corneal neovascularization (Senturk et al., 2016). Cornea transplantation, laser therapy, steroids, anti-vascular endothelial development issue (VEGF) agents, insulin receptor substrate-1 proteins, matrix metalloproteinase inhibitors, fine needle diathermy and gene therapy targeting VEGF have been broadly applied in the management of corneal neovascularization (Sharif and Sharif, 2019). Amongst them, steroids and anti-VEGF agents are at present the mainstay initial treatment approaches. Owing to their low expense and ease of 5-HT6 Receptor Modulator drug manufacture, steroids (injections and topical treatments)have come to be a vital alternative inside the prevention and treatment of corneal neovascular diseases. Triamcinolone acetonide (TA), a synthetic steroid, can routinely exerted therapeutic effects in corneal neovascularization via its vasoconstriction and inhibition of inflammation capabilities (Li et al., 2019). Eyedrops, subconjunctival injection, and intraocular injection would be the prevalent approaches for TA administration (Jonas et al., 2005; Thorne et al., 2019). Nevertheless, the all-natural ocular barriers