Name :
NKG2C/CD159c Protein
Description :
As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections.The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role in biasing adaptive immune responses upon influenza vaccination and suggests NKG2C as a potential biomarker in predicting pandemic influenza vaccine responsiveness.
Species :
Human
Uniprotkb :
HEK293
Tag :
N-His-Avi
Synonyms :
NK cell receptor C, KLRC2, CD159c, NKG2C
Construction :
Recombinant Human NKG2C/CD159c Protein is expressed from HEK293 with His tag and Avi tag at the N-Terminus. It contains Glu98-Leu231[Accession |P26717]
Protein Purity :
> 95% as determined by Tris-Bis PAGE
Molecular Weight :
The protein has a predicted MW of 15.3 kDa. Due to glycosylation, the protein migrates to 40-55 kDa based on Tris-Bis PAGE result.
Endotoxin :
Less than 1EU per μg by the LAL method.
Formulatione :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage :
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background :
As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections.The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role in biasing adaptive immune responses upon influenza vaccination and suggests NKG2C as a potential biomarker in predicting pandemic influenza vaccine responsiveness.
References and Literature :
1. Riese P, et al. Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells. Vaccines (Basel). 2020 Jun 5;8(2):28doi: 10.3390/vaccines802028PMID: 32517137; PMCID: PMC7349951.
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