Mouse B7-1/CD80 Protein 4061

Additional Information:
accession Q00609|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundCluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4.|molecular weightThe protein has a predicted MW of 24.6 kDa. Due to glycosylation, the protein migrates to 48-55 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse B7-1/CD80 Protein 4061proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceCluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4.Protein namesT-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (B7) (CD antigen CD80)Gene namesCd80,Cd80 B7Mass10090DaFunctionInvolved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.Subellular locationMembrane; Single-pass type I membrane protein.TissuesExpressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies.Target Relevance information above includes information from UniProt accession: Q00609The UniProt Consortium|