Name :
PLAU (Human) Native Protein
Biological Activity :
Human PLAU (high molecular weight) native protein from human urine.
Tag :
Protein Accession No. :
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=5328
Amino Acid Sequence :
Molecular Weight :
54
Storage and Stability :
Store at -80°C.Aliquot to avoid repeated freezing and thawing.
Host :
Human
Interspecies Antigen Sequence :
Preparation Method :
Native protein purified from human urine
Purification :
Column chromatography using several resins
Quality Control Testing :
Storage Buffer :
In 0.05 M sodium acetate, 0.1 M NaCl, pH 5.0 (1 mM EDTA)
Applications :
SDS-PAGE，
Gene Name :
PLAU
Gene Alias :
ATF, UPA, URK, UROKINASE, u-PA
Gene Description :
plasminogen activator, urokinase
Gene Summary :
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer’s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations :
OTTHUMP00000019849|U-plasminogen activator|antagonist of uPA|plasminogen activator, urinary|urokinase plasminogen activator|urokinase-type plasminogen activator amino-terminal fragment
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