beta-1 Adrenergic R/ADRB1 Antibody Summary
| Immunogen |
Peptide with sequence ESDEARRCYNDPK corresponding to internal region according to NP_000675.1.
|
| Clonality |
Polyclonal
|
| Host |
Goat
|
| Gene |
ADRB1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
|
| Application Notes |
Assay Standarization (beating frequency) successful usage of rat cardiomyocytes is reported in scientific literature (PMID: 20117461). WB: Approx. 50 kDa band observed in human heart lysates (calculated MW of 51.2 kDa band according to NP_000675.1). IP successful usage on DNA aptamers in vitro is reported in scientific literature (PMID: 21868696, 22850243).
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
|
| Theoretical MW |
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
|
| Publications |
|
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for beta-1 Adrenergic R/ADRB1 Antibody
- ADRB1
- ADRB1R
- ADRB1RRHR
- adrenergic, beta-1-, receptor
- B1AR
- beta-1 Adrenergic R
- beta-1 adrenergic receptor
- beta1 AdrenergicR
- beta-1 AdrenergicR
- Beta-1 adrenoceptor
- Beta-1 adrenoreceptor
- BETA1AR
Background
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.