ULK1 Antibody Summary
| Immunogen |
A synthetic peptide as a part of human, rat, mouse serine/threonine-protein kinase ULK1 (ULK1, ATG1, UNC51, Unc51.1, KIAA0722) conjugated to immunogenic carrier protein has been used as the immunogen.
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| Clonality |
Polyclonal
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| Host |
Sheep
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| Gene |
ULK1
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
IgG purified
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| Reconstitution Instructions |
Reconstitute with 0.5 ml sterilized water. Add glycerol (1:1) for additional stability.
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Alternate Names for ULK1 Antibody
- ATG1 autophagy related 1 homolog
- ATG1
- ATG1A
- EC 2.7.11
- EC 2.7.11.1
- FLJ38455
- FLJ46475
- KIAA0722
- serine/threonine-protein kinase ULK1
- unc-51 (C. elegans)-like kinase 1
- UNC51
- Unc51.1
- unc-51-like kinase 1 (C. elegans)
- Unc-51-like kinase 1
Background
ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Knockdown of ULK1 results in impaired endocytosis of nerve growth factor (NGF), excessive axon arborization, and severely stunted axon elongation indicating that ULK1 mediates a non clathrin coated endocytosis in sensory growth cones. Knockdown of ULK1 also inhibits the autophagic response. It appears to act as a convergence point for multiple signals that regulate autophagy, and in turn interacts with a large number of autophagy related (Atg) proteins.