Tyrosine Hydroxylase [p Ser19] Antibody Summary
| Immunogen |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser19 conjugated to KLH.
|
| Modification |
p Ser19
|
| Marker |
Neuronal Marker
|
| Specificity |
Specific for the ~60k tyrosine hydroxylase protein phosphorylated at Ser19.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TH
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
NB 300-212 can be used in Western blot, Immunohistochemistry and Immunofluorescence.
|
Reactivity Notes
Tested in Rat. Reactivity assumed based on sequence identity to a wide variety of mammalian species.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
|
| Preservative |
No Preservative
|
| Concentration |
0.1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Tyrosine Hydroxylase [p Ser19] Antibody
- DYT14
- DYT5b
- EC 1.14.16
- EC 1.14.16.2
- TH
- TYH dystonia 14
- TYH
- Tyrosine 3-hydroxylase
- tyrosine 3-monooxygenase
- Tyrosine Hydroxylase
Background
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. TH has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long term changes in activity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinsons disease is also considered a TH deficiency, as low dopamine levels are a consistent neurochemical abnormality.