Thioredoxin Reductase 1/TRXR1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human TrxR1. The exact sequence is proprietary.
|
| Localization |
Cytoplasm, Isoform 4: Cytoplasm, Nucleus, Isoform 5: Cytoplasm
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TXNRD1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Thioredoxin Reductase 1/TRXR1 Antibody
- EC 1.8.1
- EC 1.8.1.9
- Gene associated with retinoic and IFN-induced mortality 12 protein
- Gene associated with retinoic and interferon-induced mortality 12 protein
- GRIM12
- GRIM-12
- GRIM-12TR1
- KDRF
- KM-102-derived reductase-like factor
- MGC9145
- oxidoreductase
- Thioredoxin Reductase 1
- thioredoxin reductase 1, cytoplasmic
- thioredoxin reductase GRIM-12
- Thioredoxin reductase TR1
- TR
- TR1
- TRXR1
- TRXRD1
- TXNR
- TXNRD1
- TXNRTRXR1
Background
This protein is a pyridine nucleotide oxidoreductase which reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. It is thought to function as a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Alternative splicing results in several transcript variants encoding the same protein. Additional transcript variants have been described but their biological validity has not been determined.