TIA1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human TIA1. The exact sequence is proprietary.
|
| Localization |
Cytoplasmic granule
|
| Predicted Species |
Mouse (100%), Rat (90%), Monkey (100%), Bovine (99%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TIA1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Zebrafish (83%), Xenopus laevis (88%), Chicken (89%), Rhesus Monkey (100%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for TIA1 Antibody
- cytotoxic granule-associated RNA-binding protein
- nucleolysin TIA-1 isoform p40
- p40-TIA-1 (containing p15-TIA-1)
- p40-TIA-1
- RNA-binding protein TIA-1
- T-cell-restricted intracellular antigen-1
- TIA1 cytotoxic granule-associated RNA binding protein
- TIA1 cytotoxic granule-associated RNA-binding protein
- TIA-1
Background
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq]