Proteasome 19S S5A Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human PSMD4. The exact sequence is proprietary.
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| Isotype |
IgG
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| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PSMD4
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Xenopus laevis (90%), Rhesus Monkey (100%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.93 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Proteasome 19S S5A Antibody
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome regulatory subunit S5A
- AF-1,26S protease subunit S5a
- AFMCB1
- angiocidin
- Antisecretory factor 1
- ASF
- multiubiquitin chain binding protein
- Multiubiquitin chain-binding protein
- proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
- pUB-R5,26S proteasome regulatory subunit RPN10
- RPN10 homolog
- Rpn10
- S5A
- S5a/antisecretory factor protein
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq]