Neurofibromin 1 Blocking Peptide Summary
| Description |
A peptide to NF1.
|
| Specificity |
This peptide is specific for NB300-155 only.
|
| Protein/Peptide Type |
Blocking Peptide
|
| Gene |
NF1
|
Applications/Dilutions
| Application Notes |
This peptide is useful as a blocking peptide for NB300-155.For further blocking peptide related protocol, click here.
|
Packaging, Storage & Formulations
| Storage |
Store at -80C. Avoid freeze-thaw cycles.
|
| Preservative |
No Preservative
|
| Concentration |
1.0 mg/ml
|
Alternate Names for Neurofibromin 1 Blocking Peptide
- DKFZp686J1293
- FLJ21220
- Neurofibromatosis-related protein NF-1
- neurofibromin 1
- neurofibromin
- NFNS
- VRNF
- WSS
Background
Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).