NKIRAS1 Antibody Summary
| Immunogen |
Antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human KappaB ras1. The immunogen is located within the last 50 amino acids of KappaB ras1.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
NKIRAS1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody can be used for detection of KappaB ras1 by Western blot at 0.5 – 1 mg/ml.
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for NKIRAS1 Antibody
- I-kappa-B-interacting Ras-like protein 1
- kappa B-ras 1
- Kappa B-Ras protein 1
- KappaB-Ras1
- KBRAS1kappaB-Ras1
- NF-kappa-B inhibitor-interacting Ras-like protein 1
- NFKB inhibitor interacting Ras-like 1
- NFKB inhibitor interacting Ras-like protein 1
Background
KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody is specific for kappaB-ras1 and has no cross-reactivity to kappaB-ras2.