NKG2D/CD314 Antibody Summary
| Immunogen |
Peptide with sequence C-KVYSKEDQDLLK corresponding to internal region according to NP_031386.2.
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
KLRK1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 35 kDa band observed in human lymph node and human spleen lysates is reported in scientific literature (PMID: 15238421).
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for NKG2D/CD314 Antibody
- CD314 antigen
- CD314
- D12S2489E
- FLJ17759
- FLJ75772
- Killer cell lectin-like receptor subfamily K member 1
- killer cell lectin-like receptor subfamily K, member 1
- KLR
- KLRK1
- NK cell receptor D
- NKG2-D type II integral membrane protein
- NKG2D
- NKG2-D
- NKG2-D-activating NK receptor
- NKG2DDNA segment on chromosome 12 (unique) 2489 expressed sequence
Background
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. D12S2489E is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The first non-coding exon at the 5 end of the D12S2489E transcript is included in the 3 end of the KLRC4 transcript.