Meprin alpha Subunit/MEP1A Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human Meprin alpha. The exact sequence is proprietary.
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| Localization |
Membrane, Single-pass type I membrane protein
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
MEP1A
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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|
| Application Notes |
IHC-P and ICC/IF usages usage reported in scientific literature (PMID: 23427141).
|
|
| Theoretical MW |
84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Reactivity Notes
Mouse reactivity reported in scientific literature (PMID: 23427141). Rat (85%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
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Alternate Names for Meprin alpha Subunit/MEP1A Antibody
- bA268F1.1 (meprin A alpha (PABA peptide hydrolase))
- EC 3.4.24
- EC 3.4.24.18
- endopeptidase-2
- MEP1A
- meprin A subunit alpha
- meprin A, alpha (PABA peptide hydrolase)
- Meprin alpha Subunit
- N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
- PABA peptide hydrolase
- PPH alpha
- PPHA
Background
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins.