MRCK Antibody Summary
| Immunogen |
Peptide with sequence SGEVRLRQLEQFI-C corresponding to N-Terminus according to NP_003598.2.
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| Epitope |
SGEVRLRQLEQFI-C
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| Specificity |
This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CDC42BPA
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Preliminary experiments gave an approx. 30 kDa band and 40 kDa band bands in human pancreas lysates at 1 ug/ml. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated sizes of 186 kDa band according to NP_055641.3 and 196 kDa band according to NP_003598.2. IHC-P: Human cerebellum shows cytoplasm staining in Purkinje cells.
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for MRCK Antibody
- CDC42 binding protein kinase alpha (DMPK-like)
- CDC42 binidng protein kinase beta
- CDC42-binding protein kinase alpha (DMPK-like)
- CDC42-binding protein kinase alpha
- DMPK-like alpha
- EC 2.7.11
- EC 2.7.11.1
- KIAA0451DKFZp686L1738
- MRCK alpha
- MRCK
- MRCKADKFZp686P1738
- Myotonic dystrophy kinase-related CDC42-binding kinase alpha
- myotonic dystrophy kinase-related CDC42-binding protein kinase alpha
- Myotonic dystrophy protein kinase-like alpha
- PK428FLJ23347
- serine/threonine-protein kinase MRCK alpha
- ser-thr protein kinase PK428
- ser-thr protein kinase related to the myotonic dystrophy protein kinase
Background
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.