IKBKAP Antibody Summary
| Immunogen |
C-terminus of the human IKAP protein (proprietary)
|
| Specificity |
Reacts with the C terminus of IKAP.
|
| Predicted Species |
Rat (92%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
IKBKAP
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western blot: Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for their specific application.
|
Reactivity Notes
Human. Other species have not been tested. Immunogen has a 92% identity to rat, and 84% identity with mouse.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for IKBKAP Antibody
- DYS
- elongator complex protein 1
- ELP1DKFZp781H1425
- FD
- FLJ12497
- IKAPdysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy typeIII)
- IkappaB kinase complex-associated protein
- IKI3
- IKK complex-associated protein
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinasecomplex-associated protein
- p150
- TOT1
Background
The transcription factor NF-kappa B coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappa B is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes. Theses large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for 3 different kinases involved in pro-inflammatory cytokine signaling.