GPR17 Antibody Summary
| Immunogen |
Peptide with sequence C-EGKTNESSLSAKSE corresponding to C-Terminus according to NP_005282.1.
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| Epitope |
C-EGKTNESSLSAKSE
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
GPR17
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 45 kDa band observed in human brain (cerebellum), and in mouse and rat brain lysates (calculated MW of 41.0 kDa band according to human NP_005282.1 and 37.9 kDa band according to rat NP_001065245.1).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Bovine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for GPR17 Antibody
- DKFZp686M18273
- G protein-coupled receptor 17
- GPR17
- G-protein coupled receptor 17
- P2Y-like Receptor
- R12
- UDP/CysLT Receptor
- uracil nucleotide/cysteinyl leukotriene receptor
Background
GPR17, a former orphan G-coupled protein is specifically activated by P2Y and CysLT endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In both rats and humans GPR17 expressed in the organs which suffer ischemic damage, like the brain, heart and kidneys. Studies by Ciana, et. al. have shown that inhibition of GPR17 reduces ischemic damage in a rat focal ischemia model. These results suggest GPR17 is the common molecular target mediating brain damage by nucleotides and CysLTs.