GABA-A R alpha 5 Antibody (S415-24) Summary
| Immunogen |
Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA A Receptor Alpha5.
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| Localization |
Cell Junction, Synapse, Postsynaptic Cell Membrane, Cell Membrane
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| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
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| Gene |
GABRA5
|
| Purity |
Protein G purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
A 1:100 dilution of this antibody was sufficient for detection of GABA-A R, Alpha5 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
|
| Theoretical MW |
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS pH7.4, 50% glycerol
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for GABA-A R alpha 5 Antibody (S415-24)
- GABA A R alpha 5
- GABA(A) receptor subunit alpha-5
- GABAAR alpha 5
- GABAARa5
- GABRA5
- gamma-aminobutyric acid (GABA) A receptor, alpha 5
- gamma-aminobutyric acid receptor subunit alpha-5
- MGC138184
Background
The GABA A Receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). Recent research shows their usage in investigating side effects of drugs and the effects of learning and memory. Inverse agonists of the Alpha5 subunit may be useful in the treatment of Alzheimers Disease (3).