Filamin A Antibody (PM6/317) Summary
| Immunogen |
Purified human platelet plasma membrane
|
| Specificity |
Recognizes both purified Filamin A, and a 250kD protein in cell lysates. Clone PM6/317 has also been reported to work on Western blotting.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
FLNA
|
| Purity |
Tissue culture supernatant
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose. Membrane permeabilisation is required for Flow Cytometry.
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Tissue culture supernatant
|
Alternate Names for Filamin A Antibody (PM6/317)
- ABP-280DKFZp434P031
- ABPX
- actin binding protein 280
- Actin-binding protein 280
- alpha-filamin
- CVD1
- EC 2.1.1.43
- EC 6.3.4.4
- Endothelial actin-binding protein
- filamin A, alpha (actin binding protein 280)
- filamin A, alpha
- filamin-1
- filamin-A
- FLN
- FLN1OPD
- FLN-A
- FMD
- MNS
- NHBP
- Non-muscle filamin
- OPD1
- OPD2
- XLVD
- XMVD
Background
Filamin A is an actin-binding protein that crosslinks and promotes orthogonal branching of actin filaments and also functions to anchor transmembrane proteins and intracellular signaling proteins to the actin cytoskeleton. As a scaffolding protein, Filamin A is able act as a link between cell membrane receptors and intracellular signaling proteins. Defects in Filamin A are associated with multiple human diseases characterized by abnormalities in bone and neurological development.