Product: 6α-Methylprednisolone 23-hemisuccinate (sodium salt)
FGF R4 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human FGFR4. The exact sequence is proprietary.
|
| Localization |
Membrane; Single-pass type I membrane protein
|
| Predicted Species |
Bovine (92%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
FGFR4
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
88 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (89%), Rat (89%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.67 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for FGF R4 Antibody
- CD334 antigen
- CD334
- EC 2.7.10
- EC 2.7.10.1
- FGF R4
- FGFR4
- FGFR-4
- fibroblast growth factor receptor 4
- JTK2hydroxyaryl-protein kinase
- MGC20292
- protein-tyrosine kinase
- TKF
- tyrosine kinase related to fibroblast growth factor receptor
- tyrosylprotein kinase
Background
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq]