Product: PIM-447 (dihydrochloride)
DNA-PKcs Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residues 2100 and 2150 of human DNA-Dependent Protein Kinase, catalytic subunit using the numbering given in entry NP_008835.5 (GeneID 5591).
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| Predicted Species |
Monkey (100%), Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PRKDC
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Western Blot Not recommended for immunoprecipitation. Use NB 100-657, NB 100-658, or NB 100-660.
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| Positive Control |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Rhesus Monkey, Crab-eating macaque and Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
TBS and 0.1% BSA
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for DNA-PKcs Antibody
- DNA-dependent protein kinase catalytic subunit-like
- DNA-dependent protein kinase
- DNA-PK catalytic subunit
- DNAPK
- DNAPKcs
- DNA-PKcs
- DNPK1
- EC 2.7.11.1
- HYRC
- HYRC1
- p350
- p460
- PRKDC
- XRCC7
Background
DNA PK is the key component of the non-homologous end-joining (NHEJ) pathway of DSB repair in mammalian cells. DNA PK consists of a heterodimeric DNA-binding subunit (Ku70/80) and an approximately 465 kDa catalytic subunit (DNA PKcs). DNA PKcs is a serine/threonine protein kinase whose activity is greatly stimulated by its recruitment to DNA breaks by the Ku heterodimer.