Cytokeratin 16 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human Cytokeratin 16. The exact sequence is proprietary.
|
| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
KRT16
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Chimpanzee (100%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
|
| Concentration |
0.77 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Cytokeratin 16 Antibody
- CK16
- CK-16
- cytokeratin 16
- cytokeratin-16
- FNEPPK
- focal non-epidermolytic palmoplantar keratoderma
- K16
- K1CP
- keratin 16
- keratin, type I cytoskeletal 16
- keratin-16
- KRT16A
- NEPPK
Background
Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. Two cytokeratins, 6 and 16, are expressed when keratincytes are undergoing rapid turnover in various pathological states, wound healing, psoriasis and some carcinomas