Complement C3 Antibody (474) Summary
| Immunogen |
Human C3/C3a
|
| Localization |
Secreted
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| Specificity |
The reacts with an epitope on C3a. It reacts with both intact C3, as with C3a.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
C3
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
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|
| Application Notes |
Western Blot and Immunoassay: In WB predicted molecular weight 187.2 kDa. Optimal dilutions/concentrations should be determined by the end user.
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| Publications |
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Reactivity Notes
Cross-reacts with Human.Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS containing 0.1% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
0.1 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for Complement C3 Antibody (474)
- AHUS5
- ARMD9
- ASP
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
- complement C3
- complement component 3
- complement component C3
- CPAMD1acylation-stimulating protein cleavage product
Background
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.