CRMP2 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the N-terminus region of human CRMP2. The exact sequence is proprietary.
|
| Localization |
Cytoplasm
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| Isotype |
IgG
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| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
DPYSL2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Expected cross reactivity based on sequence homology: Xenopus laevis (87%) and Xenopus tropicalis (88%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.89 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for CRMP2 Antibody
- Collapsin response mediator protein 2
- CRMP-2
- CRMP2N2A3
- DHPRP2
- dihydropyrimidinase-like 2 long form
- dihydropyrimidinase-like 2
- dihydropyrimidinase-related protein 2
- DRP2collapsin response mediator protein hCRMP-2
- DRP-2ULIP-2
- ULIP2
- Unc-33-like phosphoprotein 2
Background
Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification.The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimers disease.