Product: BAY 61-3606 (dihydrochloride)
APAF-1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human APAF1. The exact sequence is proprietary.
|
| Localization |
Cytoplasm
|
| Predicted Species |
Bovine (91%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
APAF1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
142 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.51 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for APAF-1 Antibody
- APAF1
- APAF-1
- APAF-1apoptotic protease activating factor 1
- apoptotic peptidase activating factor 1
- apoptotic peptidase activating factor
- apoptotic protease activating factor
- apoptotic protease-activating factor 1
- CED4
- DKFZp781B1145
- KIAA0413
Background
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq]